Publications from our group concerning the liver's blood supply and exchange of substances with the blood

Nielsen MF, Roelsgaard K, Keiding S, Brodersen K, Möller N, Vyberg M, Vilstrup H. Impaired hepatic counterregulatory response to insulin-induced hypoglycaemia in hepatic denervated pigs. J Clin Translational Endocrinology 2015 in press

Keiding S, Munk OL. Measurements of the liver’s total blood flow and regional perfusion. In Functional Molecular Imaging in Hepatology. (eds. Keiding S, Sørensen S) Sharjah, UAE: Bentham Science Publishers 2012, pp. 14—23.

Munk OL, Keiding S, Bass L. Combining compartmental and microvascular models in interpreting dynamic PET data. In Functional Molecular Imaging in Hepatology (eds. Keiding S, Sørensen S), Sharjah, UAE: Bentham Science Publishers 2012, pp. 24—31.

Winterdahl M, Sørensen M, Keiding S, Mortensen FV, Alstrup AaKO, Hansen SB, Munk OL. Hepatic blood perfusion estimated by dynamic contrast-enhanced computed tomography: Limitations of the slope method. Investigative Radiology 2012; 47:588—595.

Winterdahl M, Munk OL, Sørensen M, Mortensen FV, Keiding S. Hepatic blood perfusion measured by 3-min dynamic FDG PET in pigs. J Nucl Med 2011; 52:1119—1124.

Winterdahl M, Keiding S, Sørensen M, Mortensen FV, Alstrup AKO, Munk OL. Tracer input for kinetic modelling of liver physiology determined without sampling portal venous blood in pigs. Eur J Nucl Med Mol Imaging 2011; 38:263—270.

Munk OL, Keiding S, Bass L. A method to estimate catheter dispersion and to calculate dispersion-free blood time-activity curves. Med Phys 2008; 35:3471—3481.

Sørensen M, Keiding S. Positron emission tomography of the liver. In Textbook of Hepatology: From Basic Science to Clinical Practice, 3. ed. (eds. Rodés J, Benhamou JP, Blei A, Reichen J and Rizzetto M), Blackwell, 2007, pp. 561—566.

Keiding S, Sørensen M. Hepatic removal kinetics: importance for quantitative measurements of liver function. In Textbook of Hepatology: From Basic Science to Clinical Practice, 3. ed. (eds. Rodés J, Benhamou JP, Blei A, Reichen J and Rizzetto M), Blackwell, 2007, pp. 468—478.

Keiding S, Munk OL, Vilstrup H, Nielsen DT, Roelsgaard K, Bass L. Hepatic microcirculation assessed by PET of first-pass ammonia metabolism in porcine liver. Liver Int 2005; 25:171—176.

Keiding S, Solvig J, Grønbæk H, Vilstrup H. Combined liver vein and spleen pulp pressure measurements in patients with portal or splenic vein thrombosis. Scand J Gastroent 2004; 39:594—599.

[Review paper] Munk OL. Hepatic metabolism of glucose analogues measured by dynamic positron emission tomography and interpreted by compartment models - with special reference to the hepatic dual-input function. (PhD-thesis 2004, Aarhus University) Dan Med Bull 2004; 51:446.

Munk OL, Bass L, Feng H, Keiding S. Determination of regional flow using intravascular PET tracers: microvascular theory and experimental validation for pig livers. J Nucl Med 2003; 44:1862—1870.

Munk OL, Keiding S, Bass L. Capillaries within compartments: microvascular interpretation of dynamic positron emission tomography data. J Theor Biol 2003; 225:127—141.

Munk OL, Keiding S, Bass L. Impulse-response function of splanchnic circulation with model-independent constraints: theory and experimental validation. Am J Physiol Gastrointest Liver Physiol 2003; 285:G671—G680.

Keiding S, Vilstrup H. Intrahepatic heterogeneity of hepatic venous pressure gradient in human cirrhosis. Scand J Gastroeterol 2002; 37:960—964.

Weiss M, Roelsgaard K, Bender D, Keiding S. Determinants of [13N]ammonia kinetics in hepatic PET experiments: a minimal recirculatory model. Eur J Nucl Med 2002; 29:1648—1656.

Munk OL, Bass L, Roelsgaard K, Bender D, Hansen SB, Keiding S. Liver kinetics of glucose analogs measured in pigs by PET: Importance of dual-input blood sampling. J Nucl Med 2001; 42:795—801.

Ott P, Clemmesen O, Keiding S. Interpretation of simultanous measurements of hepatic extraction fractions of indocyanine green and sorbitol: Evidence of hepatic shunts and capillarization? Dig Dis Sci 2000; 45:359—365.

Keiding S, Munk OL, Schiøtt KM, Hansen SB. Dynamic 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography of liver tumors without blood sampling. Eur J Nucl Med 2000; 27:407—412.

Keiding S, Engsted E, Ott P. Sorbitol as a test substance for measurement of liver plasma flow in humans. Hepatology 1998; 28:50—56.

Ott P, Bass L, Keiding S. Hepatic ICG removal in the pig depends on plasma protein and hematocrit: Evidence of sinusoidal binding disequilibrium and unstirred water layer effects. Hepatology 1997; 26:679—690.

Keiding S, Ott P, Bass L. Enhancement of unbound clearance of ICG by plasma protein, demonstrated in human subjects and interpreted without assumption of facilitating structures. J Hepatol 1993; 19:327—344.

Ott P, Keiding S, Bass L. Intrinsic hepatic clearance of indocyanine green in the pig: Dependence on plasma protein concentration. Eur J Clin Invest 1992; 22:347—357.

Keiding S, Skak C. Methodological limitations of the use of intrinsic hepatic clearance of ICG as a measure of liver cell function. Eur J Clin Invest 1988; 18:507—511.

Keiding S. Galactose clearance and liver blood flow. Gastroenterol 1988; 94:477—481.

Bass L, Keiding S. Physiologically based models and strategic experiments in hepatic pharmacology. Biochem Pharmacol 1988; 37:1425—1431.

[Review paper] Winkler K, Bass L, Keiding S, Tygstrup N. The physiologic basis of clearance measurements in hepatology. Scand J Gastroenterol 1979; 14:439—448.

Keiding S, Chiarantini E. Effect of sinusoidal perfusion on galactose elimination kinetics in perfused rat liver. J Pharm Exp Ther 1978; 205:465—470.



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