Publications from our group concerning hepatic metabolism and excretory function

Ørntoft NW, Gormsen LC, Keiding S, Munk OL, Ott P, Sørensen M. Hepatic bile acid transport increases in the postprandial state. A functional 11C-CSar PET/CT study in healthy humans. J Hep Reports in press as of 2021

Kjærgaard K, Frisch K, Sørensen M, Munk OL, Hofmann AF, Horsager J, Schacht AC, Erickson M, Shapiro D, Keiding S. Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis. J Hepatol 2021;74:58—65.

Keiding S, Frisch K, Hofmann AF. Reply to: “Obeticholic acid and hepatic bile acids: Excellent study faulty conclusion” by Javitt NB. J Hep 2021

Kjærgaard K, Sandahl T, Frisch K, Vase KH, Keiding S, Vilstrup H, Ott P, Gormsen LC, Munk OL. Intravenous and oral copper kinetics, biodistribution and dosimetry in healthy humans studied by [64Cu]copper PET/CT. EJNMMI Radiopharmacy and Chemistry 2020;5:15.

Frisch K, Stimson DHR, Venkatachalam T, Pierens GK, Keiding S, Reutens D, Bhalla R. N-(4-[18F]fluorobenzyl)cholylglycine, a novel tracer for PET of enterohepatic circulation of bile acids: Radiosynthesis and proof-of-concept studies in rats. Nucl Med Biol 2018;1:56—62.

Ørntoft N, Frisch K, Ott P, Keiding S, Sørensen M. Functional assessment of hepatobiliary secretion by 11C-cholylsarcosine positron emission tomography. BBA - Molecular Basis of Disease; Special issue: Cholangiocytes 2018;1864:1240—1244.

Keiding S, Sørensen M, Frisch K, Gormsen LC, Munk OL. Quantitative PET of liver functions. Am J Nucl Med Mol Imaging 2018 Apr 25;8:73—85.

Munk OL, Keiding S, Baker C, Bass L. A microvascular compartment model validated using 11C-methylglucose liver PET in pigs. Phys Med Biol 2017;63:015032.

Horsager J, Lausten SB, Bender D, Munk OL, Keiding S. Hepatic metabolism of 11C-methionine and secretion of 11C-protein measured by PET in pigs. Am J Nucl Med Mol Imaging 2017;7:167—173.

Bak-Fredslund KP, Eriksen PL, Munk OL, Villadsen GE, Keiding S, Sørensen M. Metabolic liver function in humans measured by 2-[18F]fluoro-2-deoxy-D-galactose PET/CT - reproducibility and clinical potential. EJNMMI Research 2017;7:71.

Ørntoft NW, Munk OL, Frisch K, Ott P, Keiding S, Sørensen M. Hepatobiliary transport kinetics of the conjugated bile acid tracer 11C-CSar quantified in healthy humans and patients by Positron Emission Tomography (PET). J Hepatol 2017;67:321—327.

Sørensen M, Munk OL, Ørntoft NW, Frisch K, Andersen KJ, Mortensen FV, Alstrup AK, Ott P, Hofmann AF, Keiding S. Hepatobiliary secretion kinetics of conjugated bile acids measured in pigs by 11C-Cholylsarcosine PET. J Nucl Med 2016; 57:961—966.

Nielsen MF, Roelsgaard K, Keiding S, Brodersen K, Møller N, Vyberg M, Vilstrup H. Impaired hepatic counter-regulatory response to insulin-induced hypoglycemia in hepatic denervated pigs. J Clin Translat Endocrinology 2015;2:131—136.

Keiding S. How should lumped constant be estimated for hepatic 18F-FDG glucose in humans? J Nucl Med 2015;56:1302—1303.

Horsager J, Munk OL, Sørensen M. Metabolic liver function measured in vivo by dynamic (18)F-FDGal PET/CT without arterial blood sampling. EJNMMI Res 2015; 5:32—37.

Mikkelsen KS, Sørensen M, Frisch K, Villadsen GE, Bibby BM, Keiding S. The lumped constant for the galactose analog 2-[18F]fluoro-2-deoxy-D-galactose is increased in patients with parenchymal liver disease. J Nucl Med 2014; 55:590—594.

Heebøll S, Villadsen GE, Aagaard NK, Grønbæk H, Vilstrup H, Keiding S. Propranolol treatment of portal hypertension in cirrhosis patients is better the higher the untreated pressure: a single-centre prospective experience. Scand J Gastroent 2013;48:969—973.

Sørensen M, Mikkelsen KS, Frisch K, Villadsen GE, Keiding S. Regional metabolic liver function measured in patients with cirrhosis by 2-[18F]fluoro-2-deoxy-D-galactose PET/CT. J Hepatol 2013; 58:1119—1124.

Frisch K, Sørensen M, Hofmann AF, Keiding S. Positron emission tomography of hepatobiliary transport: development of 11C-cholyl-sarcosine, a PET-tracer for conjugated bile acids. In XXII International Bile Acid Meeting - Hepatic and Extrahepatic Targets of Bile Acid Signaling (eds. Häussinger D, Beuers U, Trauner M), Falk Symposium 184, Vienna, 2012. Basel, Switzerland: S. Karger AG, 2013, pp. 96—103.

Winterdahl M, Sørensen M, Keiding S, Mortensen FV, Alstrup AaKO, Hansen SB, Munk OL. Hepatic blood perfusion estimated by dynamic contrast-enhanced computed tomography: Limitations of the slope method. Investigative Radiology 2012; 47:588—595.

Frisch K, Hofmann AF. Biliary secretion. In Functional Molecular Imaging in Hepatology (eds. Keiding S, Sørensen M), Bentham Science Publishers, 2012,49—75.

Bass L, Sørensen M, Munk OL, Keiding S. Calculating the metabolic clearance of a mother substance from the clearance of its analogue tracer measured by PET. In Functional Molecular Imaging in Hepatology (eds. Keiding S, Sørensen S), Bentham Science Publishers, 2012,32—36.

Frisch K, Jakobsen S, Sørensen M, Munk OL, Alstrup AKO, Ott P, Hofmann AF, Keiding S. [N-methyl-11C]Cholylsarcosine, a novel bile acid tracer for PET/CT of hepatic excretory function: Radiosynthesis and proof-of-concept studies in pigs. J Nucl Med 2012; 53:772—778.

Sørensen M, Mikkelsen KS, Frisch K, Bass L, Bibby BM, Keiding S. Hepatic galactose metabolism quantified in humans using 2-[18F]fluoro-2-deoxy-D-galactose PET/CT. J Nucl Med 2011; 52:1566—1572

Bass L, Sørensen M, Munk OL, Keiding S. Analogue tracers and lumped constant in capillary beds. J Theor Biol 2011; 285:177—181.

Dam G, Keiding S, Munk OL, Ott P, Buhl M, Vilstrup H, Bak LK, Waagepetersen HS, Schousboe A, Møller N, Sørensen M. Branched-chain amino acids increase arterial blood ammonia in spite of enhanced intrinsic muscle ammonia metabolism in patients with cirrhosis and healthy subjects. Am J Physiol Liver Gastroent 2011; 301: G269—277.

Frisch K, Bender D, Keiding S, Sørensen M. Nucleophilic radiosynthesis of 2-[18F]fluoro-2-deoxy-D-galactose from Talose triflate and biodistribution in a porcine mode. Nuc Med Biol 2011; 38:477—483.

Sørensen M. Determination of hepatic galactose elimination capacity using 2-[18F]fluoro-2-deoxy-D-galactose PET/CT. Reproducibility of the method and metabolic heterogeniety in a normal pig liver model. Scand J Gastroenterol 2011; 46:98—103.

Lange A, Grønbæk H, Vilstrup H, Keiding S. Age-dependency of galactose elimination capacity in healthy children and children with chronic liver disease. Scand J Gastroent 2011; 46:197—200.

Keiding S, Sørensen M, Munk OL, Bender D. Human 13N-ammonia PET studies: The importance of measuring (13)N-ammonia metabolites in blood. Metab Brain Dis 2010;25:49—56.

Jepsen P, Vilstrup H, Ott P, Keiding S, Andersen PK, Tygstrup N. The galactose elimination capacity and mortality in 781 Danish patients with newly-diagnosed liver cirrhosis: a cohort study. BMJ Gastroenterol 2009; 9:50.

Dam G, Sørensen M, Munk OL, Keiding S. Hepatic ethanol elimination kinetics in patients with cirrhosis. Scand J Gastroent 2009; 44:867—871.

Munk OL, Keiding S, Bass L. A method to estimate catheter dispersion and to calculate dispersion-free blood time-activity curves. Medical Physics 2008; 35:3471—3481.

Sørensen M, Munk OL, Mortensen FV, Olsen AK, Bender D, Bass L, and Keiding S. Hepatic uptake and metabolism of galactose can be quantified in vivo by 2-[18F]fluoro-2-deoxygalactose positron emission tomography. Am J Physiol Gastrointest Liver Physiol 2008; 295:G27—G36.

Bender D, Munk OL, Feng H, Keiding S. Metabolites of 18F-FDG and 3-O-11C-methylglucose in pig liver. J Nucl Med 2001; 42:1673—1678.

Weiss M, Roelsgaard K, Bender D, Keiding S. Determinants of [13N]ammonia kinetics in hepatic PET experiments: a minimal recirculatory model. Eur J Nucl Med 2002; 29:1648—1656.

Munk OL, Bass L, Roelsgaard K, Bender D, Hansen SB, Keiding S. Liver kinetics of glucose analogs measured in pigs by PET: Importance of dual-input blood sampling. J Nucl Med 2001; 42:795—801.

Keiding S, Munk OL, Roelsgaard K, Bender D, Bass L. Positron emission tomography of hepatic first-pass metabolism of ammonia in pig. Eur J Nucl Med 2001; 28:1770—1775.

Roelsgaard K, Bøtker HE, Stødkilde-Jørgensen H, Andreasen F, Jensen SL, Keiding S. Effects of brain death and glucose infusion on hepatic glycogen and blood hormones in the pig. Hepatology 1996; 24:871—875.

Ott P, Bass L, Keiding S. The kinetics of continuously infused indocyanine green in the pig. J Pharmacokinetics Biopharm 1996; 24:19—44.

Kjær M, Keiding S, Engfred K, Rasmussen K, Sonne B, Kirkegaard P, Galbo H. Glucose homeostasis during exercise in humans with a liver or kidney transplant. Am J Phys 1995; 268:E636—644.

Keiding S, Johansen S, Tygstrup N. Galactose removal kinetics during hypoxia in perfused pig liver: Reduction of Vmax, but not of intrinsic clearance Vmax/Km. Eur J Clin Invest 1990; 20:305—309.

Keiding S, Johansen S, Winkler K. Hepatic galactose elimination kinetics in the intact pig liver. Scand J clin Lab Invest 1982; 42:253—259.

Keiding S, Chiarantini E. Effect of sinusoidal perfusion on galactose elimination kinetics in perfused rat liver. J Pharm Exp Ther 1978; 205:465—470.

Winkler K, Keiding S, Tønnesen K, Tygstrup N. The effect of physiological temperature changes on the galactose elimination capacity of the isolated perfused pig liver. Clin Physiol 1986; 6:381—387.

Keiding S, Johansen S, Midtbøll I, Rabøl A, Christiansen L. Ethanol elimination kinetics in pig liver and human liver. Am J Physiol 1979; 237:E316—324.

Keiding S, Johansen S, Winkler K, Tønnesen K, Tygstrup N. Michaelis-Menten kinetics of galactose elimination by the isolated perfused pig liver. Am J Physiol 1976; 320:1302—1313.

Bass L, Keiding S, Winkler K, Tygstrup N. Enzymatic elimination of substrates flowing through the intact liver. J theor Biol 1976; 61:393—409.



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