Publications from our group concerning hepatic encephalopathy

Iversen P, Mouridsen K, Hansen MB, Jensen SB, Sørensen M, Bak LK, Waagepetersen HS, Schousboe A, Ott P, Vilstrup H, Keiding S, Gjedde A. Oxidative metabolism of astrocytes is not reduced in hepatic encephalopathy: A PET study with [11C]acetate in humans. Frontiers in Neuroscience 2014; 8:353.

Fries AW, Dadsetan S, Keiding S, Bak LK, Schousboe A, Waagepetersen HS, Simonsen M, Ott P, Vilstrup H, Sørensen M. Effect of glutamine synthetase inhibition on brain and interorgan ammonia metabolism in bile duct ligated rats. J Cerebral Blood Flow Metab 2014; 111:2283—2288.

Keiding S, Pavese N. Brain metabolism in patients with hepatic encephalopathy studied by PET and MR. Arch Biochem Biophysics 2013; 536:131—142.

Dadsetan S, Kukolj E, Bak LK, Sørensen M, Ott P, Vilstrup H, Schousboe A, Keiding S, Waagepetersen HS. Brain alanine formation as an ammonia scavenging pathway during hyperammonemia: effects of inhibited glutamine synthetase in rats and astrocyte-neuron co-cultures. J Cerebral Blood Flow Metab 2013; 33:1235—1241.

Sørensen M. Update on cerebral uptake of blood ammonia. Met Brain Dis 2013; 28:155—159.

Bak LK, Waagepetersen HS, Sørensen M, Ott P, Vilstrup H, Keiding S, Schousboe A. Role of branched chain amino acids in cerebral ammonia homeostasis related to hepatic encephalopathy. Met Brain Dis 2013, 28:209—215.

Dam G, Keiding S, Munk OL, Ott P, Vilstrup H, Bak LK, Waagepetersen HS, Schousboe A, Sørensen M. Reply to: "Venous blood ammonia can be associated with cerebral blood flow in hepatic encephalopathy" by Zheng G et al. Hepatology 2013; 58:833—834.

Dam G, Keiding S, Munk OL, Ott P, Vilstrup H, Bak L, Waagepetersen HS, Schoueboe A, Sørensen M. Hepatic encephalopathy is associated with decreased brain oxygen metabolism and blood flow, not increased ammonia uptake. Hepatology 2013; 57:258—265.

Leke R, Oliveira DL, Forgiarini LF, Escobar TD, Hammes TO, Meyer FS, Keiding S, Silveira TR, Schousboe A. Impairment of short term memory in rats with hepatic encephalopathy due to bile duct ligation. Metab Brain Dis 2013, 28:187—192.

Dadsetan S, Sørensen M, Bak LK, Vilstrup H, Ott P, Schousboe A, Jalan R, Keiding S, Waagepetersen HS. Interorgan metabolism of ornithine phenylacetate – A novel strategy for treatment of hyperammonemia. Biochem Pharm 2012; 85:115−123.

Leke R, de Oliveira DL, Mussulini BHM, Pereira MS, Kazlauckas V, Mazzini G, Hartmann CR, Silveira TR, Simonsen M, Bak LK, Waagepetersen HS, Keiding S, Schousboe A, Portela LV. Impairment of the organization of locomotor and exploratory behaviors in bile duct—ligated rats. PLoS ONE 2012; 7:e36322.

Iversen S, Keiding S, Mouridsen K, Ott P, Vilstrup H. Transjugular intrahepatic portosystemic shunt does not alter cerebral blood flow. Clin Gastroent Hepatol 2011; 9:1001—1003.

Leke R, Bak LB, Iversen P, Sørensen M, Keiding S, Vilstrup H, Ott P, Portela LV, Schousboe A, Waagepetersen HS. Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy. J Neurochem 2011; 117:824—832.

Dadsetan S, Bak LB, Sørensen M, Keiding S, Vilstrup H, Ott P, Leke R, Schousboe, Waagepetersen HS. Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons. Neurochem Int 2011; 59:482—488.

Leke R, Bak LK, Anker M, Melø TM, Sørensen M, Keiding S, Vilstrup H, Ott P, Portela LV, Sonnewald U, Schousboe A, Waagepetersen H S. Detoxification of ammonia in mouse cortical GABAergic cell cultures increases neuronal oxidative metabolism and reveals an emerging role for release of glucose-derived alanine. Neurotox Res 2011; 19:496—510.

Gjedde A, Keiding S, Vilstrup H, Iversen P. No oxygen delivery limitation in hepatic encephalopathy. Metab Brain Dis 2010; 25:57—63.

Keiding S, Sørensen M, Munk OL, Bender D. Human13N-ammonia PET studies: The importance of measuring 13N-ammonia metabolites in blood. Metab Brain Dis 2010; 25:49—56.

[Review paper] Berding G, Banati RB, Buchert R, Chierichetti F, Grover VP, Kato A, Keiding S, Taylor-Robinson SD. Radiotracer imaging studies in hepatic encephalopathy: ISHEN practice guidelines. Liver Int 2009; 29:621—628.

Iversen P, Sørensen M, Bak LK, Waagepetersen HS, Vafaee MS, Borghammer P, Mouridsen K, Jensen SB, Vilstrup H, Schousboe A, Ott P, Gjedde A, Keiding S. Low cerebral oxygen consumption and blood flow in patients with cirrhosis and an acute episode of hepatic encephalopathy. Gastroenterology 2009; 136:863—871.

Bass L, Keiding S, Munk OL. Benefits and risks of transforming data from dynamic positron emission tomography, with an application to hepatic encephalopathy. J Theor Biol 2009; 256:632—636.

Bak L, Iversen P, Sørensen M, Keiding S, Vilstrup H, Ott P, Gjedde A, Waagepetersen HS, Schousboe A. Metabolic fate of isoleucine in a rat model of hepatic encephalopathy and in cultured neural cells exposed to ammonia. Metab Brain Dis 2009; 24:135—145.

Sørensen M, Munk OL, Keiding S. Backflux of ammonia from brain to blood in human subjects with and without hepatic encephalopathy. Metab Brain Dis 2009; 24:237—242.

Johansen ML, Bak LK, Schousboe A, Iversen P, Sørensen M. Keiding S, Vilstrup H, Gjedde A, Ott P, Waagepetersen HS. The metabolic role of isoleucine in detoxification of ammonia in cultered mouse neurons and atrocytes. Neurochem Int 2007; 50:1042—1051.

[Review paper in Danish] Sørensen M, Vilstrup H, Keiding S, Ott P. Hepatisk encefalopati. Ugeskr Læger 2007; 169:1106.

Sørensen M, Keiding S. New findings on cerebral ammonia uptake in HE using functional 13N-ammonia PET. Metabolic Brain Disease 2007; 22:277—284.

Schousboe A, Waagepetersen HS, Bak LK, Johansen ML, Keiding S, Vilstrup H, Iversen P, Sørensen M. Når skrumpelever får hjernen til at slå fra. Lægemiddelforskning 2006, Institute of Pharmacology and Pharmacotherapy, University of Copenhagen.

Sørensen M, Keiding S. Reply to: "Permeability surface products for brain ammonia metabolism" by Lockwood A and Wack DS. Hepatology 2006; 44:1053—1054.

[Review paper] Sørensen M, Keiding S. Ammonia metabolism in cirrhosis. In Hepatic Encephalopathy and Nitrogen Metabolism (eds. Häussinger D, Kircheis G, Schliess F), Springer 2006, pp. 406—419.

Keiding S, Sørensen M, Bender D, Munk OL, Ott P, Vilstrup H. Brain metabolism of 13N-ammonia during acute hepatic encephalopathy in cirrhosis measured by PET. Hepatology 2006; 43:42—50.

Iversen P, Hansen DAa, Bender D, Rodell A, OL, Cumming P, Keiding S. Peripheral benzodiazepine receptors in the brain of patients with cirrhosis and manifest hepatic encephalopathy. Eur J Nucl Med Mol Imaging 2006; 33:810—816.